microRNA-based
Three circulating microRNAs — miR-21, miR-24 and miR-155 — reflect inflammation, cellular ageing and metabolism. Their interplay is used to calculate a biological age, which is then set against the chronological one.
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Metabolic HealthHealthy AgingBiological Age ClockTelomere AnalysisStress MonitorHealthy SportThe principle
microRNAs are small RNA molecules that regulate how strongly individual genes are read. Three of them — miR-21, miR-24 and miR-155 — stand for inflammation, cellular ageing and metabolism. A regression model uses their interplay to calculate a biological age and sets it against chronological age. Because microRNAs respond dynamically, changes can show up comparatively quickly.
miR-21 (inflammation), miR-24 (senescence and repair) and miR-155 (immune balance and metabolism).
microRNA levels change with diet, exercise, sleep, stress and smoking.
What carries meaning is the development between two measurements under the same conditions — not the single value.
The process
Dried blood spot card, from the fingertip. microRNA expression by qPCR, normalised against miR-93. No fasting required.
A multivariate regression model uses the three signals to calculate the biological age and its deviation from chronological age.
Specific nutrition and lifestyle levers for each signal, plus follow-up monitoring at the next measurement.
How reliable is this figure?
The underlying model has been published as a pilot study (n = 539). It explains around 5% of the variance in age, the mean absolute error is 10.4 years, and two of the three microRNAs did not correlate significantly with chronological age in that work. The authors themselves call for validation before clinical use.
Your result
From the combined evaluation of miR-21, miR-24 and miR-155. Chronological age 48 years. Your biological age is 52 years, four years above your chronological age. The range from −5 to +5 years is regarded as age-appropriate — your value therefore lies within this range. For context: the reference band of ±5 years is narrower than the model's mean error of 10.4 years. A deviation of this magnitude therefore cannot be distinguished from the model's scatter.
Biological versus chronological
Chronological age 48 years.
Where you stand
Two scores from your self-reported information, each compared with the reference.
Basis of the calculation
The individual signals on a scale of 1–9; higher is better. Only their interplay produces the age clock — a single signal on its own does not permit any conclusion.
Lead microRNA of ‘inflammaging’. Rises with chronic, low-grade inflammation and is closely linked to senescence and fibrosis.
The weakest of your three signals. All eight recommendations in this report address the miR-21 pathway.
Central switch of the immune response. Elevated levels accompany metabolic stress and overactive inflammatory regulation.
In the lower middle range. Together with miR-21, this signal points in the same direction: inflammation and immune regulation are the axis of this report.
Regulates cell division, DNA repair and apoptosis. Reflects the repair capacity and senescence level of cells.
The strongest of your three signals — exactly in the middle of the scale. Repair capacity and senescence level are unremarkable.
Where you stand
The radar shows how close your current habits are to the reference values. The further out a factor lies, the more favourable — 10 is optimal.
72 / 100
Nutrition
Good nutrient combination, room for improvement in the details.
Reference: ≥ 60
65 / 100
Lifestyle
Balanced, with room for more physical activity and stress reduction.
Reference: ≥ 60
Link to the age clock
Assessment based on your self-reported information, not an individual diagnosis. The associations described come from the model study and are group findings, not a prediction for the individual case.
All recommendations at a glance
Eight levers, each assigned to the microRNA signals they act on, together with their current values. Sorted by urgency — the weakest signal first.
| Lever | Acts on | Source | Amount | Note |
|---|---|---|---|---|
| Resveratrol | miR-21 · 3 | Grape skins, blueberries, peanuts | 150–500 mg/day | Activates sirtuins, inhibits NF-κB |
| Omega-3 fatty acids | miR-21 · 3, miR-155 · 4 | Salmon, mackerel, herring, linseed; alternatively algal oil | 2×/week, 150–200 g | Anti-inflammatory; associated with a younger miRNA age in the model |
| EGCG (green tea) | miR-21 · 3, miR-155 · 4 | Green tea, matcha, sencha | 300–400 mg/day (3–4 cups) | Antioxidant; favourable lifestyle factor in the model |
| Curcumin | miR-21 · 3, miR-155 · 4 | Turmeric, with black pepper | 1 tsp daily | Piperine markedly increases absorption |
| Sulforaphane | miR-21 · 3, miR-155 · 4 | Broccoli (and broccoli sprouts), cauliflower, Brussels sprouts, cress | 25 mg/day (approx. 250 g) | Heating for 3–4 min at 80 °C increases bioavailability |
| Sleep and stress | miR-21 · 3, miR-155 · 4 | Restorative sleep, stress regulation, not smoking | daily | Stress and smoking were associated with a higher miRNA age in the model |
| Physical activity | miR-21 · 3, miR-155 · 4, miR-24 · 5 | Endurance and strength combined | ≥ 150 min/week | Regular activity was associated with a lower miRNA age in the model |
| Quercetin | miR-21 · 3, miR-24 · 5 | Onion, garlic, capers, kale | 500–1,000 mg/day | Senolytic; better bioavailability with vitamin C |
Table scrolls sideways
The ‘acts on’ assignment denotes the pathway the respective lever targets. It is not a promise of a measurable change in the individual case. Please review food supplements individually and in consultation with a qualified professional; this overview does not replace medical advice.
Trend
Because the single value does not overcome the model's scatter, the informative value of this analysis lies in the trend. Only measured values are shown — no forecast.
Evaluation: initial measurement 15.03.2026, follow-up 15.06.2026, change −2 years, deviation today +4 compared with chronological age.
What the trend shows
Biological age has fallen by two years between the two measurements, from 54 to 52 — while chronological age rose by three months over the same period. The direction is right.
Summary
Two of your three signals — miR-21 (3/9) and miR-155 (4/9) — describe inflammation and immune regulation, and both lie in the lower range. miR-24, which reflects repair and senescence, sits in the middle at 5/9. This produces a clear picture of where to focus.
All eight levers in this report act on miR-21, six of them additionally on miR-155. The overlap is manageable and practical for everyday life. Specifically: oily sea fish twice a week or algal oil daily, 3–4 cups of green tea, turmeric with black pepper, broccoli cooked for 3–4 minutes at 80 °C, berries for resveratrol.
Your lifestyle radar shows stress at 4 out of 10 as the weakest factor, with exercise at 7 and omega-3 at 6 leaving room for improvement. In the model study, stress and smoking were associated with a higher miRNA age, while regular physical activity and fish were associated with a lower one. Physical activity is the only lever that targets all three signals at once: at least 150 minutes per week, endurance and strength combined.
What is already working
Not smoking (tobacco 9/10), fruit and vegetables (8/10) and fluid intake (8/10) are well above the reference group. The nutrition score of 72/100 is solid as well. And the trend is pointing in the right direction.
Please keep in mind
What is established — and what is not
We set out the limits of this analysis openly, because an honest interpretation is worth more than an impressive number.
Pilot study; validation called for by the authors themselves
n = 539
around 5%
10.4 years
1 of 3
As a consultation and monitoring tool: it creates a concrete occasion, makes lifestyle topics tangible and, through repeated measurements under the same conditions, provides a trend line.
As an age determination, as a statement about life expectancy or disease risk, as diagnostics — and as a basis for comparison with methylation-based age clocks, which rest on a different methodology and a different evidence base.
Schneider J. et al., miRNA-3Age: a microRNA-based biological age model and its modulation by lifestyle and nutrition. Frontiers in Nutrition (2025), doi:10.3389/fnut.2025.1659730
This document does not replace medical assessment and does not constitute any promise of cure within the meaning of the German Therapeutic Products Advertising Act (HWG).
The guiding principle
The trend carries the meaning, the single value does not. An initial and a follow-up measurement under the same conditions are the real benefit of this analysis.
Discuss the results with the institution that carried out the sample collection. That is where the context needed for interpretation is available.
Contact
Distribution
Sample report. All values and personal details in this document are fictitious and serve solely to illustrate the report format. This is not a real report.
Interpretation. The biological age reported here is a model value derived from three microRNA signals. The underlying model has been published as a pilot study; its mean absolute error is around ten years. The value is not an age determination, not a diagnosis and not a statement about life expectancy or disease risk. Informative value only emerges across several measurements under the same conditions. A comparison with methylation-based age clocks is not permissible.
Legal framework. The laboratory analysis is carried out by our cooperation partner. Polaris Diagnostics Europe GmbH is responsible for distribution and support. Please review food supplements individually and in consultation with a qualified professional. This document does not constitute any promise of cure within the meaning of the German Therapeutic Products Advertising Act (HWG).
© 2026 Polaris Diagnostics Europe GmbH · As at: August 2026
All six documents are sample reports: every value, genotype and personal detail is fictitious and serves solely to illustrate the report format. These are not real results.
The other sample reports
