Sample report · Example data

Metabolic Health

Genetics and Epigenetics

Your metabolic profile on two levels: the inherited genetic predisposition and the epigenetic markers that can be changed through diet, exercise, sleep and stress.

Report for: Muster, Erika
Sample collection: 08.04.2026
Material: Dried blood spot card
Evaluations: 17 + 4 epigenetic

The principle

How to read this report.

This report combines two levels: your genetics — inherited and unchangeable — and your epigenetics, which can be influenced by lifestyle. Both are shown on the same scale.

Level 1 · Genetics

Your genes are the blueprint of your metabolism: how you process carbohydrates, fats and proteins, how appetite and satiety work, how your body handles vitamins and salt. These predispositions do not change.

Level 2 · Epigenetics

Epigenetics does not show which genes you have, but how active they currently are. These four values can be changed — and are therefore the only ones in which the effect of an intervention can be demonstrated over time.

Orientation

How do I read the scale?

All evaluations — genetic and epigenetic alike — use the same traffic-light scale from 1 to 9. Red on the left, green on the right: 1–3 red, 4–6 amber, 7–9 green. Higher is always more favourable.

13579

1–3 · Red: Outside the optimal range. This is where the greatest leverage lies.
4–6 · Amber: Moderate need for support. Monitor specifically.
7–9 · Green: In the favourable range. Maintain existing routines.

Important

This report is not a diagnosis. Interpretation takes place in consultation with qualified professionals and always in the individual context.
Information and written consent are required before a genetic analysis (German Genetic Diagnostics Act, GenDG).
The genetic values never change. Only the four epigenetic values are suitable for monitoring progress.

Results at a glance

Your four modifiable values.

These four markers change through diet, exercise, sleep and stress. They are the part of the report in which an effect can be measured — and the reason for a follow-up measurement.

Marker	Level	Your value	Optimal	Interpretation
LINE-1 · DNA stability	Methylation	2 / 9	7–9	Outside range
Inflammation regulation (IL-6 & TNF-α)	Methylation	7 / 9	7–9	Optimal
miR-21 · Inflammation & micronutrients	microRNA	3 / 9	7–9	Outside range
miR-155 · FTO regulation, adipose tissue	microRNA	8 / 9	7–9	Optimal

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Your metabolic type: balanced type

Your metabolism does not favour any one of the three macronutrients. Recommended distribution: 55 % carbohydrates · 20 % protein · 25 % fat, with a calculated requirement of 1,900 kcal/day.

Your exercise type: endurance type

ACE and ACTN3 point to an endurance predisposition. Longer, steady exertion suits you better than short bursts of strength — a strength component nevertheless remains important.

What follows from this

Two red values — LINE-1 (2/9) and miR-21 (3/9). Both depend on folate, zinc and methylation metabolism; the genetic MTHFR variant (2/9) points in the same direction. This is the central starting point of this report.
Two green values — inflammation regulation (7/9) and miR-155 (8/9) are in the optimal range and should be kept there.
A follow-up measurement is meaningful after 4 to 6 months at the earliest.

Results at a glance

All genetic evaluations.

Seventeen evaluations on the 1–9 traffic-light scale. These values are inherited and do not change — they describe where your metabolism needs more support than average.

Skin hydrationAQPR9/9· Favourable

Difficulty maintaining weight8/9· Favourable

Salt sensitivity8/9· Favourable

Obesity risk7/9· Favourable

Vitamin DTransport, GC7/9· Favourable

Oxidative cell protectionSOD27/9· Favourable

Food cravings6/9· Moderate

Skin elasticity & inflammationIL-66/9· Moderate

Difficulty losing weight5/9· Moderate

B vitaminsRequirement5/9· Moderate

Hunger/satiety regulation4/9· Moderate

Antioxidant capacityNADPH4/9· Moderate

Diabetes risk3/9· Increased need

Blood lipids & fatty acid metabolism2/9· Increased need

Omega-3 supplyALA → EPA/DHA2/9· Increased need

FolateMTHFR2/9· Increased need

Weight loss through exerciseFTO2/9· Increased need

Sorted by value, not by topic. The detailed interpretation with genotypes and interventions follows from page 07.

Epigenetic status

Methylation.

DNA methylation shows how active your genes currently are — governed by diet, exercise, sleep and stress. Unlike the genes themselves, these values can be changed.

LINE-1DNA stability

LINE-1 elements make up around 17 % of the genome. Their methylation is regarded as a marker of global DNA regulation.

2 / 9Outside range

159

Your value lies outside the optimal range. This marker is most effectively supported through the nutrients involved in folate metabolism — which gains additional importance given your MTHFR variant (genetic 2/9).

Measure	Source	Amount / frequency	Effect
Folic acid	green leafy vegetables, tomato, pulses, nuts, sprouts	daily	If needed, 2 months as methylfolate (5-MTHF)
Riboflavin (B2)	germinated seeds, sprouts, cheese	daily	Cofactor of methylation
Cobalamin (B12)	egg, cheese, fermented foods	daily	Regeneration of active folate
Methionine	Brazil nuts, sesame, soya, peas, leafy vegetables	daily	Direct methyl group donor
Pyridoxine (B6)	cabbage, green beans, lentils, bananas	daily	Cofactor of methylation
Fibre	wholegrains, vegetables, pulses	at least 30 g/day	Bioavailability of phytochemicals

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Inflammation regulation (IL-6 & TNF-α)

Combined score from the methylation of both gene regions — not the acute blood level. Individual values: IL-6 8/9 · TNF-α 6/9.

7 / 9Optimal

159

Your combined value is in the optimal range. A plant-focused, low-inflammatory diet continues to work preventively against a rising level of TNF-α.

Measure	Source	Amount / frequency	Effect
Resveratrol	grape skins, raspberry seeds, blueberries, peanuts	1 portion of berries/day	Regulates immune cells, inhibits NF-κB
Sulforaphane	broccoli, cauliflower, Brussels sprouts, cress	3–4×/week	Anti-inflammatory, antioxidant
Quercetin	onions, garlic, capers, chives	daily	Let onions stand for 10 min after chopping
Curcumin	turmeric with black pepper	1 tsp daily	Inhibits DNA methyltransferases

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Epigenetic status

microRNA.

microRNAs fine-tune the activity of your genes and reflect current metabolic and inflammatory activity. Like methylation, they can be influenced through lifestyle.

miR-21Inflammation and micronutrients

Worsens with more pronounced inflammatory activity as well as with a poor zinc and folate supply.

3 / 9Outside range

159

With a red or amber value, a normal BMI should be aimed for; in addition, targeted zinc and folate intake is worthwhile. Antioxidant micronutrients such as vitamin D, vitamin E and lycopene as well as resveratrol support immune regulation.

Measure	Source	Amount / frequency	Effect
Zinc	pumpkin seeds, oats, lentils, cheese, beef	daily	A poor zinc supply worsens this value
Folate	leafy vegetables, pulses, tomato, sprouts	daily	A poor folate supply worsens this value
Resveratrol	grape skins, blueberries, peanuts	1 portion of berries/day	Inhibits the NF-κB signalling pathway
Vitamin D	salmon, butter, egg, avocado, mushrooms	regularly	Important for immune regulation
Vitamin E	wheatgerm oil, nuts, spinach, broccoli	daily	Antioxidant, protects cell membranes
Lycopene	tomatoes, melon, carrots, papaya	daily	Carotenoid with an antioxidant effect

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miR-155FTO regulation and adipose tissue formation

Central regulator of immune and inflammatory responses; influences the formation of brown and beige adipose tissue.

8 / 9Optimal

159

Your result is in the optimal range. Exercise, fasting and cold stimuli have an additional favourable effect, activate the formation of brown and beige adipose tissue and influence the FTO effect positively — particularly relevant because your genetic FTO evaluation is 2/9.

Measure	Source	Amount / frequency	Effect
Regular exercise	endurance and strength combined	150 min/week	Demonstrably has a favourable effect on this value
Cold stimuli	cold showers, ice bathing, cool rooms	regularly, briefly	Activates brown/beige adipose tissue
Fasting phases	extended overnight break from eating	after consultation	Supports the activation of brown adipose tissue
Quercetin	onions, garlic, capers, chives	at least 200 mg/day	Influences mitochondrial biogenesis

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Genetics · Macronutrients

Metabolic type: balanced type.

Your metabolism does not particularly favour any one of the three macronutrients. The general recommendation of the DACH reference values therefore applies to you — a good starting position that requires no special adjustment of the distribution. More important in your case is the quality of the foods.

Share	Macronutrient	Note
55 %	Carbohydrates	Wholegrains, pulses and vegetables as the basis
20 %	Protein	20–30 g per main meal
25 %	Fat	Focus on unsaturated fats

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Individually calculated daily energy requirement: 1,900 kcal.

Genetics · Exercise

Exercise type: endurance type.

Both ACE and ACTN3 point to a predisposition for endurance performance. For context: genetics explains only up to around 20 % of the difference between strength and endurance performance — training, diet and consistency have by far the greater influence.

Gene	Your genotype	Predisposition
ACE	GG (homozygous)	Rather endurance — variant associated with better oxygen utilisation and efficiency.
ACTN3	TT (wild type)	Rather endurance — XX type without α-actinin-3, more slow, endurance-oriented muscle fibres.

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Genetics · Exercise

Weight loss through exercise.

Weight loss through exerciseFTO rs1121980

Genotype AT (heterozygous). How much exercise alone contributes to weight loss.

2 / 9Increased need

159

In your case, exercise alone leads to weight loss somewhat more slowly than with other genotypes. The effect on fitness and metabolic health remains unchanged — for weight reduction, the combination of exercise and dietary adjustment is particularly worthwhile.

Measure	Source	Amount / frequency	Effect
Endurance component	cycling, running, swimming	2–3×/week	Oxygen supply, basic endurance
Strength component	full-body strength training	2×/week	Maintains muscle mass and metabolic activity
Combine with diet	see metabolic type recommendation	individual	With FTO, the most effective additional lever

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Genetics · Metabolism

Obesity and diabetes predisposition.

Genetic predisposition for excess weight and for blood sugar metabolism — as a starting point for targeted nutrition, not as a prediction.

Obesity risk

Summary of variants that are associated with an increased risk of excess weight.

7 / 9Genotypes: FTO rs9939609 TT · PPARG2 CC (wild type) · MC4R CT · TCF7L2 CT · SLC6A14 CA · TFAP2B GGFavourable

159

Your result is in the favourable range — the genetic background does not indicate an increased risk. Meal structure, fibre and regular exercise maintain this good starting position.

Measure	Source	Amount / frequency	Effect
Fibre	wholegrains, pulses, vegetables	at least 30 g/day	Prolongs satiety, stabilises blood sugar
Protein per meal	eggs, pulses, fish, meat	20–30 g/meal	Supports satiety signals
Exercise	—	150 min/week	Demonstrably attenuates genetically driven effects

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Diabetes risk

Genes that influence insulin secretion, insulin sensitivity and blood sugar metabolism.

3 / 9Genotypes: TCF7L2 CT · IL-6 CG · ADRB3 GG (wild type) · PPARG2 CCIncreased need

159

Your value lies outside the favourable range. Carbohydrate quality and regular exercise are the most effective levers in your case — and, together with the red miR-21 value, the second focus of this report.

Measure	Source	Amount / frequency	Effect
Low glycaemic index	wholegrains, pulses, vegetables	every main meal	Avoids sharp blood sugar peaks
Movement after eating	short walk	10–15 min	Measurably improves insulin sensitivity

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Genetics · Eating behaviour

Nutrition type.

Satiety, food cravings and the tendency to lose or maintain weight — your genetic levers around eating behaviour.

Food cravings

6 / 9MC4R CT · FTO rs9939609 TT · LEPR AA · SLC6A14 CA · PPARG2 CCModerate

159

A slightly increased tendency towards spontaneous eating impulses. Meal structure and protein intake are your most effective levers here.

Measure	Source	Amount / frequency	Effect
Protein with every meal	eggs, pulses, fish, meat, tofu	20–30 g/meal	Strongest known satiety signal
Regular meals	—	3 fixed times/day	Reduces blood sugar fluctuations

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Hunger and satiety regulation

4 / 9MC4R, LEPR and FTO rs1121980 (AT) togetherModerate

159

A somewhat delayed satiety signal — slow, mindful eating gives this signal the time it needs.

Measure	Source	Amount / frequency	Effect
Slow, mindful eating	—	at least 20 min/meal	Gives the delayed signal time
High-fibre diet	vegetables, wholegrains	at least 30 g/day	Prolongs the feeling of fullness

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Losing weight

5 / 9ADRB3 GG · PLIN CT

159

Increased need for support with sleep and leptin sensitivity. 7–9 hrs of sleep and combined training 2–3×/week.

Maintaining weight

8 / 9TCF7L2 CT

159

Favourable starting position against the yo-yo effect. Stable meal times and 150 min of exercise/week maintain it.

Genetics · Micronutrients

Vitamin uptake.

How well your body utilises vitamin D and converts folate into its active form — including the resulting requirement for B vitamins.

FolateMTHFR

Genotype homozygous variant. Key enzyme in folate metabolism.

2 / 9Increased need

159

Your MTHFR variant indicates a markedly limited conversion of folate into its active form (5-MTHF). Your requirement for folate from food is higher than with other genotypes. This value also explains the red LINE-1 marker on the epigenetic level — both depend on the same metabolic pathway.

Measure	Source	Amount / frequency	Effect
Folate from food	green leafy vegetables, pulses, asparagus	2–3 portions/day	MTHFR variants benefit from a consistently high intake
Active folate (5-MTHF)	if required, as a food supplement	after consultation with a doctor	Bypasses the limited conversion directly

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Vitamin DTransport

GC (vitamin D-binding protein), genotype GT (heterozygous)

7 / 9Favourable

159

Vitamin D transport in your blood is only slightly limited. This does not mean a deficiency, but it does make a blood level check worthwhile during the months with little sunlight.

Measure	Source	Amount / frequency	Effect
Vitamin D	oily fish, eggs; sunlight	15–20 min/day regularly, check levels	Checking is worthwhile above all in winter
Vitamin K2	fermented foods, egg yolk, hard cheese	daily	Supports vitamin D in bone and vascular metabolism

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B vitaminsRequirement

Follows from the MTHFR variant via the methylation cycle.

5 / 9Moderate

159

Measure	Source	Amount / frequency	Effect
Vitamin B2	eggs, dairy products, wholegrains	daily	Direct cofactor of the MTHFR enzyme
Vitamin B6	potatoes, pulses, bananas	daily	Homocysteine metabolism
Vitamin B12	eggs, fish, dairy products	daily	Regeneration of active folate

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Genetics · Lipid metabolism

Omega 3 and blood lipids.

How well you utilise plant-based omega-3 precursors and how your blood lipid levels are genetically predisposed.

Blood lipids and fatty acid metabolism

2 / 9FADS1 TT · APOA5 AG · LPL AA (wild type) · PPARG2 CCIncreased need

159

Your FADS1 variant indicates that the body converts plant-based omega-3 precursors (ALA) into the active forms EPA and DHA only to a limited extent. It is more practical to take in EPA and DHA directly. The separate evaluation “Omega-3 supply” looks exclusively at this conversion step and is likewise 2 / 9.

Measure	Source	Amount / frequency	Effect
EPA and DHA directly	oily sea fish (salmon, mackerel, herring); alternatively algal oil	fish 2×/week or algal oil daily	Bypasses the limited FADS1 conversion
Plant-based omega-3 sources	linseed oil, walnuts, chia seeds	in addition, not as the sole source	In your case only partly converted
Limit omega-6	sunflower, safflower and corn oil sparingly	in everyday life	Favourable omega-6 to omega-3 ratio
Reduce sugar and white flour	in favour of wholegrains	in everyday life	Counteracts elevated triglycerides (APOA5)

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Genetics · Blood pressure

Salt sensitivity.

Salt sensitivity

8 / 9ACE, genotype GG (homozygous)Favourable

159

Your ACE variant shows no increased salt sensitivity. As a general rule: anyone who eats a saltier diet should deliberately drink more so that excess salt is excreted via the kidneys.

Measure	Source	Amount / frequency	Effect
Keep an eye on salt intake	processed foods, ready meals	max. 6 g salt/day	Reduces water retention
Drink enough	water, unsweetened tea	at least 1.5–2 l/day	Supports sodium excretion
Potassium from vegetables and fruit	bananas, potatoes, green vegetables	daily	Counteracts salt-related retention

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Genetics · Skin and antioxidants

Nutricosmetics.

Skin elasticity, hydration and antioxidant protection — how diet supports your skin from within.

Skin hydration

9 / 9AQPR CC (wild type)

159

Your skin retains moisture well — a normal care routine is usually sufficient. Supportive: at least 1.5–2 l of water daily.

Oxidative cell protection

7 / 9SOD2 AG (heterozygous)

159

Solid protection against oxidative stress. Daily antioxidants and consistent UV protection maintain this starting position.

Skin elasticity and inflammation

IL-6 CG (heterozygous). Increased activity can accelerate collagen breakdown.

6 / 9Moderate

159

A moderate tendency towards inflammation in the skin — an anti-inflammatory diet has a visible effect on your skin.

Measure	Source	Amount / frequency	Effect
Omega-3 fatty acids	salmon, linseed, walnuts	fish 2×/week	Supports the skin barrier
Antioxidants	berries, colourful vegetables, green tea	daily	Counteracts oxidative stress

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Antioxidant capacity

NADPH AG (heterozygous). Provides the reducing power for cellular antioxidant systems.

4 / 9Moderate

159

A moderately reduced antioxidant capacity — an intake of antioxidants through the diet provides additional support for your skin.

Measure	Source	Amount / frequency	Effect
Antioxidants	berries, colourful vegetables, green tea	daily	Supports the cellular defence against free radicals
UV protection	sunscreen, headwear	when exposed to the sun	Reduces the oxidative burden on the skin

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Genetic basis

All genes analysed.

The complete list of the variants examined together with your genotype. These values are inherited and remain unchanged throughout life — repeating the genetic analysis serves no purpose.

Gene	Your genotype	Function
FTO rs9939609	TT (homozygous)	Risk allele A. Associated with BMI, body fat mass and waist circumference when the intake of saturated fatty acids is high.
FTO rs1121980	AT (heterozygous)	Risk allele A. Responds less well to weight loss through physical activity.
MTHFR	homozygous variant	Key enzyme in folate and methylation metabolism; influences the homocysteine level.
FADS1	TT (homozygous)	Controls the conversion of plant-based omega-3/-6 precursors into the active, long-chain fatty acids.
APOA5	AG (heterozygous)	Regulates the breakdown of triglycerides in the blood and influences blood lipid levels.
LPL	AA (wild type)	Breaks down fats from the blood; influences HDL cholesterol and blood lipid levels.
PPARG2	CC (wild type)	Regulates fat cell formation, fat storage and insulin sensitivity; influences appetite and satiety.
PLIN	CT (heterozygous)	Coats fat droplets in fat cells and regulates their build-up and breakdown.
ADRB3	GG (wild type)	Regulates fat burning in fat cells and the utilisation of stored fat.
MC4R	CT (heterozygous)	Centrally involved in controlling appetite, hunger and satiety signals in the brain.
LEPR	AA (homozygous)	Transmits the satiety signal of the hormone leptin.
SLC6A14	CA (heterozygous)	Transports amino acids; influences appetite, satiety and stress eating.
TCF7L2	CT (heterozygous)	Influences insulin secretion after carbohydrate-rich meals.
TFAP2B	GG (wild type)	Involved in the regulation of body weight and fat distribution.
IL-6	CG (heterozygous)	Central messenger substance of inflammation regulation; influences blood lipids, appetite and stress eating.
GC	GT (heterozygous)	Influences the transport of vitamin D in the blood.
ACE	GG (homozygous)	Part of the bradykinin-aldosterone system; influences endurance/strength predisposition and salt sensitivity.
ACTN3	TT (wild type)	Influences muscle fibre composition (fast vs. slow fibres).
AQPR	CC (wild type)	Influences water retention in the skin.
NADPH	AG (heterozygous)	Contributes to the antioxidant capacity of the cells.
SOD2	AG (heterozygous)	Important antioxidant enzyme, protects cells from oxidative stress.

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21 variants. Each of the evaluations on page 04 is derived from several of these genes together; a single genotype on its own does not allow any conclusion.

Summary

Your three focus areas.

From 21 genes and four epigenetic markers, three areas emerge in which effort and effect meet most clearly in your case.

Methylation metabolism — folate, B vitamins, zinc

Three values point in the same direction: LINE-1 2/9 (epigenetic), miR-21 3/9 (epigenetic) and folate/MTHFR 2/9 (genetic). This is no coincidence — all three depend on the same metabolic pathway. This is where the greatest leverage of this report lies, and it is at the same time the only area whose effect can be demonstrated in a follow-up measurement. In concrete terms: green leafy vegetables and pulses daily, B2/B6/B12 via eggs, cheese and fermented foods, zinc via pumpkin seeds, oats and lentils. Active folate (5-MTHF) for two months after consultation with a doctor.

Fat quality — EPA and DHA directly

Blood lipids 2/9 and omega-3 supply 2/9. Your FADS1 variant makes plant-based omega-3 sources alone insufficient: linseed oil and walnuts are only partly converted. Oily sea fish twice a week or algal oil daily bypasses this bottleneck directly. At the same time, use omega-6-rich oils sparingly.

Blood sugar quality rather than calorie quantity

Diabetes risk 3/9 alongside a favourable obesity value (7/9). For you, the quality of the carbohydrates counts for more than the quantity: a low glycaemic index at every main meal, 20–30 g of protein per meal and a short walk after eating. Since exercise alone works more slowly in your case (FTO 2/9), this combination is the more effective route.

Follow-up and next step

A follow-up measurement of the four epigenetic markers is meaningful after 4 to 6 months at the earliest — before that, changes cannot be measured reliably.
The genetic evaluations remain unchanged and never need to be repeated.
A comparison of the measurement points over time is reported from the second measurement onwards.

Questions about your report?

Discuss the results with the facility that carried out the sample collection. That is where the clinical context needed for interpretation is available.

Contact

contact@polarisdx.net
+49 152 2858 0999
www.polarisdx.net

Distribution

Polaris Diagnostics Europe GmbH
Große Bleichen 1–3
20354 Hamburg

Sample report. All values, genotypes and personal details in this document are fictitious and serve solely to illustrate the report format. This is not a real report.

Interpretation. This report is not a diagnosis and does not replace medical advice. Genetic evaluations describe predispositions, not diseases; epigenetic markers describe a momentary state. Both are to be assessed in the individual clinical context by qualified professionals.

Legal framework. Genetic testing is subject to the German Genetic Diagnostics Act (GenDG); information and written consent are required before sample collection. The laboratory analysis is carried out by our cooperation partner. Polaris Diagnostics Europe GmbH is responsible for distribution and support.

All six documents are sample reports: every value, genotype and personal detail is fictitious and serves solely to illustrate the report format. These are not real results.

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